Reactome | Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex

Schema > Reaction > Entries

Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122962
displayName	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
eventOf	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Homo sapiens
input	[Complex:R-RNO-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
output	[Complex:R-RNO-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-RNO-195275] Phosphorylation of APC component of the destruction complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-195280
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-RNO-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
(inferredTo)	[Reaction:R-HSA-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex

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