Reactome | Phosphorylation of APC component of the destruction complex

Schema > Reaction > Entries

Phosphorylation of APC component of the destruction complex Show undefined attributes

catalystActivity	[CatalystActivity:10122958] protein serine/threonine kinase activity of p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122960
displayName	Phosphorylation of APC component of the destruction complex
eventOf	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-195275] Phosphorylation of APC component of the destruction complex - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-195282] p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of APC component of the destruction complex
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-RNO-195300] Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-195275
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-RNO-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
(inferredTo)	[Reaction:R-HSA-195275] Phosphorylation of APC component of the destruction complex