Reactome | Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex

Schema > Reaction > Entries

Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10163614
displayName	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
eventOf	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex - Homo sapiens
input	[Complex:R-RNO-206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Complex:R-RNO-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
output	[Complex:R-RNO-2130280] RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol]
precedingEvent	[Reaction:R-RNO-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2130279
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-RNO-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
(inferredTo)	[Reaction:R-HSA-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex

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