Reactome | CYP19A1 hydroxylates TEST to EST17b

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CYP19A1 hydroxylates TEST to EST17b Show undefined attributes

catalystActivity	[CatalystActivity:9999003] steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	9999052
displayName	CYP19A1 hydroxylates TEST to EST17b
eventOf	[Pathway:R-RNO-193144] Estrogen biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193143] CYP19A1 hydroxylates TEST to EST17b - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-193057] TEST [cytosol]
isInDisease	false
isInferred	true
name	CYP19A1 hydroxylates TEST to EST17b Testosterone is converted to estradiol
output	[SimpleEntity:R-ALL-193132] EST17b [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-RNO-193064] HSD17B3-like proteins reducde ANDST to TEST - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193143
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193144] Estrogen biosynthesis
(inferredTo)	[Reaction:R-HSA-193143] CYP19A1 hydroxylates TEST to EST17b