Reactome | Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers

Schema > Reaction > Entries

Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10152374
displayName	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
eventOf	[Pathway:R-RNO-1250342] PI3K events in ERBB4 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Rattus norvegicus [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers - Homo sapiens
input	[DefinedSet:R-RNO-1250351] p-ERBB4cyt1 homodimers [plasma membrane] [Complex:R-RNO-1806218] PIK3CA:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
output	[Complex:R-RNO-1250373] PI3K:p-ERBB4cyt1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-1250315] Trans-autophosphorylation of ERBB4 homodimers - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1250353
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1250342] PI3K events in ERBB4 signaling
(precedingEvent)	[Reaction:R-RNO-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers

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