Reactome | Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers

Schema > Reaction > Entries

Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10152363
displayName	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
eventOf	[Pathway:R-RNO-1963642] PI3K events in ERBB2 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Rattus norvegicus [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers - Homo sapiens
input	[CandidateSet:R-RNO-1963568] Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] [Complex:R-RNO-1806218] PIK3CA:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
output	[Complex:R-RNO-1306974] NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane]
precedingEvent	[Reaction:R-RNO-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Rattus norvegicus [Reaction:R-RNO-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1250346
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1963642] PI3K events in ERBB2 signaling
(precedingEvent)	[Reaction:R-RNO-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers