Reactome | Apoa1 [extracellular region]

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-8855688] enlarged spherical HDL [extracellular region] - Rattus norvegicus [Complex:R-RNO-8855688] enlarged spherical HDL [extracellular region] - Rattus norvegicus [Complex:R-RNO-8855688] enlarged spherical HDL [extracellular region] - Rattus norvegicus [Complex:R-RNO-8855688] enlarged spherical HDL [extracellular region] - Rattus norvegicus [Complex:R-RNO-2395765] nascent CM:atREs [extracellular region] - Rattus norvegicus [Complex:R-RNO-174769] spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Rattus norvegicus [Reaction:R-RNO-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Rattus norvegicus [Reaction:R-RNO-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 - Rattus norvegicus [Reaction:R-RNO-264848] apoA-I binds to CUBN:AMN - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10119389
displayName	Apoa1 [extracellular region]
endCoordinate	267
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-174720] APOA1(25-267) [extracellular region] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-RNO-482769] Platelet releasate secretory granule proteins [extracellular region] - Rattus norvegicus [DefinedSet:R-RNO-2173760] Ligands of MSR1 [extracellular region] - Rattus norvegicus
name	Apoa1 APOA1(25-267) P04639
positivelyRegulates	[PositiveRegulation:10128958] Positive regulation by 'APOA1(25-266) [extracellular region]'
producedByEvent	[Reaction:R-RNO-264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:P04639] UniProt:P04639
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-174720
startCoordinate	25

(hasComponent)	[Complex:R-RNO-2395765] nascent CM:atREs [extracellular region] [Complex:R-RNO-2395771] mature CM:atREs [extracellular region] [Complex:R-RNO-174769] spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] [Complex:R-RNO-174798] TG-depleted chylomicron [extracellular region] [Complex:R-RNO-8855688] enlarged spherical HDL [extracellular region] [Complex:R-RNO-174697] chylomicron [extracellular region] [Complex:R-RNO-174791] nascent chylomicron [extracellular region] [Complex:R-RNO-349645] pre-beta HDL [extracellular region] [Complex:R-RNO-2168878] HPR:APOL1:APOA1:HDL3 [extracellular region] [Complex:R-RNO-9707686] oxidized discoidal HDL [extracellular region] [Complex:R-RNO-9707670] oxidized spherical HDL [extracellular region] [Complex:R-RNO-216752] discoidal HDL [extracellular region] [Complex:R-RNO-265523] spherical HDL [extracellular region]
(hasMember)	[DefinedSet:R-RNO-482769] Platelet releasate secretory granule proteins [extracellular region] [DefinedSet:R-RNO-2173760] Ligands of MSR1 [extracellular region]
(input)	[Reaction:R-RNO-264848] apoA-I binds to CUBN:AMN [Reaction:R-RNO-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle [Reaction:R-RNO-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1
(regulator)	[PositiveRegulation:10128958] Positive regulation by 'APOA1(25-266) [extracellular region]'
(output)	[Reaction:R-RNO-264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-174720] APOA1(25-267) [extracellular region]

Apoa1 [extracellular region] Show undefined attributes

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