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Apoa1 [extracellular region]
Stable Identifier
R-RNO-174720
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
APOA1(25-266), P04639
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Heme signaling (Rattus norvegicus)
FeHM oxidises LDL,HDL (Rattus norvegicus)
LDL,HDL [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
oxidized LDL,HDL [extracellular region] (Rattus norvegicus)
oxidized discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
oxidized spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
Release of platelet secretory granule components (Rattus norvegicus)
Platelet releasate secretory granule proteins [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of fat-soluble vitamins (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
CR:atREs binds apoE and HSPG (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
CR:atREs:HSPG:apoE [plasma membrane] (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Cytosolic CMs translocate to extracellular region (Rattus norvegicus)
nascent CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LPL hydrolyses TGs from mature CMs (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
mature CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)
CR:atREs:HSPG:apoE [plasma membrane] (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Nascent CMs transform into mature CMs (Rattus norvegicus)
mature CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
nascent CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
CR:atREs binds apoE and HSPG (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
CR:atREs:HSPG:apoE [plasma membrane] (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Cytosolic CMs translocate to extracellular region (Rattus norvegicus)
nascent CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LPL hydrolyses TGs from mature CMs (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
mature CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)
CR:atREs:HSPG:apoE [plasma membrane] (Rattus norvegicus)
CR:atREs [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Nascent CMs transform into mature CMs (Rattus norvegicus)
mature CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
nascent CM:atREs [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
Plasma lipoprotein assembly (Rattus norvegicus)
Chylomicron assembly (Rattus norvegicus)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Rattus norvegicus)
chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
nascent chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)
nascent chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
HDL assembly (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
pre-beta HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Plasma lipoprotein clearance (Rattus norvegicus)
HDL clearance (Rattus norvegicus)
Disassembly of SR-BI-bound spherical HDL (Rattus norvegicus)
pre-beta HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
HDLBP binds HDL (Rattus norvegicus)
HDLBP:HDL [plasma membrane] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
apoA-I binds to CUBN:AMN (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Plasma lipoprotein remodeling (Rattus norvegicus)
Chylomicron remodeling (Rattus norvegicus)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
chylomicron [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
HDL remodeling (Rattus norvegicus)
Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
discoidal HDL:cholesterol [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Rattus norvegicus)
LCAT:discoidal HDL complex [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)
LCAT:spherical HDL complex [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Rattus norvegicus)
LCAT:discoidal HDL complex [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)
LCAT:spherical HDL complex [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Rattus norvegicus)
enlarged spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Binding and Uptake of Ligands by Scavenger Receptors (Rattus norvegicus)
Scavenging by Class A Receptors (Rattus norvegicus)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)
MSR1:Ligand [plasma membrane] (Rattus norvegicus)
Ligands of MSR1 [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Scavenging by Class B Receptors (Rattus norvegicus)
Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)
Platelet glycoprotein IV:Ligand [plasma membrane] (Rattus norvegicus)
Ligands of CD36 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
SCARB1 (SR-BI, CLA-1) binds ligands (Rattus norvegicus)
Ligands of SCARB1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
SCARB1:Ligand [plasma membrane] (Rattus norvegicus)
Ligands of SCARB1 [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Scavenging of heme from plasma (Rattus norvegicus)
Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Rattus norvegicus)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Rattus norvegicus)
Apoa1 [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P04639
Gene Names
Apoa1
Reference Genes
BioGPS Gene:25081 Apoa1
ENSEMBL:ENSRNOG00000045679
ENSEMBL:ENSRNOG00000045679.3 Apoa1
ENSEMBL:ENSRNOG00055019759
ENSEMBL:ENSRNOG00060014072
ENSEMBL:ENSRNOG00065027868
KEGG Gene (Rattus norvegicus):25081 Apoa1
Monarch:25081 Apoa1
NCBI Gene:25081 Apoa1
Reference Transcript
RefSeq:NM_012738.1 Apoa1
Other Identifiers
10940638
1368335_at
17882689
17882690
25081
5873058
5914401
6733488
A_44_P411097
GE19932
GO:0005576
GO:0006869
GO:0008289
GO:0042157
J02597cds_s_at
M00001_i_at
PH_rn_0004076
Participates
as a member of
Platelet releasate secretory granule proteins [extracellular region] (Rattus norvegicus)
Ligands of MSR1 [extracellular region] (Rattus norvegicus)
as a component of
nascent CM:atREs [extracellular region] (Rattus norvegicus)
mature CM:atREs [extracellular region] (Rattus norvegicus)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Rattus norvegicus)
TG-depleted chylomicron [extracellular region] (Rattus norvegicus)
enlarged spherical HDL [extracellular region] (Rattus norvegicus)
chylomicron [extracellular region] (Rattus norvegicus)
nascent chylomicron [extracellular region] (Rattus norvegicus)
pre-beta HDL [extracellular region] (Rattus norvegicus)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Rattus norvegicus)
oxidized spherical HDL [extracellular region] (Rattus norvegicus)
oxidized discoidal HDL [extracellular region] (Rattus norvegicus)
discoidal HDL [extracellular region] (Rattus norvegicus)
spherical HDL [extracellular region] (Rattus norvegicus)
as an input of
apoA-I binds to CUBN:AMN (Rattus norvegicus)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)
as an output of
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)
This entity regulates
Positively
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
(Rattus norvegicus)
Other forms of this molecule
Apoa1 [secretory granule lumen]
Apoa1 [cytosol]
Apoa1 [early endosome]
Apoa1 [endoplasmic reticulum lumen]
Apoa1 [extracellular region]
Apoa1 [plasma membrane]
Apoa1 [endocytic vesicle lumen]
phospho-Apoa1 [endoplasmic reticulum lumen]
Apoa1 [endoplasmic reticulum lumen]
Inferred From
APOA1(25-266) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_036870.1
Ensembl
ENSRNOP00000065206
,
ENSRNOG00000045679
,
ENSRNOT00000074357
PRO
P04639
RGD
2130
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7TMA5
20
Apob [cytosol]
(R-RNO-2395786)
Apob [early endosome]
(R-RNO-2429651)
Apob [lysosomal lumen]
(R-RNO-8876369)
Apob [plasma membrane]
(R-RNO-171089)
Apob [clathrin-coated endocytic vesicle membrane]
(R-RNO-171155)
Apob [endosome lumen]
(R-RNO-171119)
Apob [endosome membrane]
(R-RNO-171121)
Apob [clathrin-coated endocytic vesicle membrane]
(R-RNO-174788)
Apob [plasma membrane]
(R-RNO-174625)
Apob [endoplasmic reticulum lumen]
(R-RNO-174620)
Apob [extracellular region]
(R-RNO-174770)
Apob [endoplasmic reticulum membrane]
(R-RNO-174637)
Apob [smooth endoplasmic reticulum]
(R-RNO-8866317)
Apob [endocytic vesicle lumen]
(R-RNO-2512789)
Apob [endocytic vesicle lumen]
(R-RNO-2239461)
Apob [endocytic vesicle lumen]
(R-RNO-2239446)
Apob [extracellular region]
(R-RNO-2173751)
Apob [extracellular region]
(R-RNO-171065)
Apob [extracellular region]
(R-RNO-2173702)
Apob [endoplasmic reticulum membrane]
(R-RNO-6784882)
0.544
2
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