Reactome | APOA1(25-267) [extracellular region]

Schema > EntityWithAccessionedSequence > Entries

APOA1(25-267) [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-8855688] enlarged spherical HDL [extracellular region] - Homo sapiens [Complex:R-HSA-8855688] enlarged spherical HDL [extracellular region] - Homo sapiens [Complex:R-HSA-8855688] enlarged spherical HDL [extracellular region] - Homo sapiens [Complex:R-HSA-8855688] enlarged spherical HDL [extracellular region] - Homo sapiens [Complex:R-HSA-2395765] nascent CM:atREs [extracellular region] - Homo sapiens [Complex:R-HSA-174769] spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Homo sapiens [Reaction:R-HSA-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Homo sapiens [Reaction:R-HSA-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 - Homo sapiens [Reaction:R-HSA-264848] apoA-I binds to CUBN:AMN - Homo sapiens
created	[InstanceEdit:174717] D'Eustachio, P, 2006-02-20 17:46:54
dbId	174720
displayName	APOA1(25-267) [extracellular region]
endCoordinate	267
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-174720] Apoa1 [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-RNO-174720] Apoa1 [extracellular region] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-174720] APOA1 [extracellular region] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-174720] APOA1 [extracellular region] - Bos taurus [EntityWithAccessionedSequence:R-SSC-174720] APOA1 [extracellular region] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-174720] apoa1a [extracellular region] - Danio rerio [EntityWithAccessionedSequence:R-XTR-174720] apoa1 [extracellular region] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-174720] APOA1 [extracellular region] - Gallus gallus
maxDepth	1
memberOf	[DefinedSet:R-HSA-482769] Platelet releasate secretory granule proteins [extracellular region] - Homo sapiens [DefinedSet:R-HSA-2173760] Ligands of MSR1 [extracellular region] - Homo sapiens
modified	[InstanceEdit:9967163] D'Eustachio, Peter, 2025-09-26
name	APOA1(25-267) apoA-I apolipoprotein A-I
positivelyRegulates	[PositiveRegulation:R-HSA-264701] Positive regulation by 'APOA1(25-266) [extracellular region]'
producedByEvent	[BlackBoxEvent:R-HSA-1989754] Expression of APOA1 - Homo sapiens [Reaction:R-HSA-264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P02647] UniProt:P02647 APOA1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-174720
startCoordinate	25
updateTrackers	[UpdateTracker:9886963] Update Tracker - [EntityWithAccessionedSequence:174720] APOA1(25-266) [extracellular region] - v45:[addName] [UpdateTracker:9867146] Update Tracker - [EntityWithAccessionedSequence:174720] APOA1(25-266) [extracellular region] - v25:[modifyEndCoordinate] [UpdateTracker:9972156] Update Tracker - [EntityWithAccessionedSequence:174720] APOA1(25-267) [extracellular region] - v95:[modifyEndCoordinate, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9886963] Update Tracker - [EntityWithAccessionedSequence:174720] APOA1(25-266) [extracellular region] - v45:[addName] [UpdateTracker:9867146] Update Tracker - [EntityWithAccessionedSequence:174720] APOA1(25-266) [extracellular region] - v25:[modifyEndCoordinate] [UpdateTracker:9972156] Update Tracker - [EntityWithAccessionedSequence:174720] APOA1(25-267) [extracellular region] - v95:[modifyEndCoordinate, modifyName]
(output)	[BlackBoxEvent:R-HSA-1989754] Expression of APOA1 [Reaction:R-HSA-264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
(hasComponent)	[Complex:R-HSA-2395765] nascent CM:atREs [extracellular region] [Complex:R-HSA-2395771] mature CM:atREs [extracellular region] [Complex:R-HSA-2395766] CR [extracellular region] [Complex:R-HSA-174769] spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] [Complex:R-HSA-174798] TG-depleted chylomicron [extracellular region] [Complex:R-HSA-8855688] enlarged spherical HDL [extracellular region] [Complex:R-HSA-174697] chylomicron [extracellular region] [Complex:R-HSA-174791] nascent chylomicron [extracellular region] [Complex:R-HSA-349645] pre-beta HDL [extracellular region] [Complex:R-HSA-2168878] HPR:APOL1:APOA1:HDL3 [extracellular region] [Complex:R-HSA-9707670] oxidized spherical HDL [extracellular region] [Complex:R-HSA-9707686] oxidized discoidal HDL [extracellular region] [Complex:R-HSA-216752] discoidal HDL [extracellular region] [Complex:R-HSA-265523] spherical HDL [extracellular region]
(hasMember)	[DefinedSet:R-HSA-482769] Platelet releasate secretory granule proteins [extracellular region] [DefinedSet:R-HSA-2173760] Ligands of MSR1 [extracellular region]
(input)	[Reaction:R-HSA-264848] apoA-I binds to CUBN:AMN [Reaction:R-HSA-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle [Reaction:R-HSA-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1
(regulator)	[PositiveRegulation:R-HSA-264701] Positive regulation by 'APOA1(25-266) [extracellular region]'

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