Reactome | MyD88:MAL(TIRAP) cascade initiated on plasma membrane

Schema > Pathway > Entries

MyD88:MAL(TIRAP) cascade initiated on plasma membrane Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222827
displayName	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
eventOf	[Pathway:R-RNO-168179] Toll Like Receptor TLR1:TLR2 Cascade - Rattus norvegicus [Pathway:R-RNO-166016] Toll Like Receptor 4 (TLR4) Cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259820] MyD88-dependent toll-like receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Rattus norvegicus [Pathway:R-RNO-937042] IRAK2 mediated activation of TAK1 complex - Rattus norvegicus [Pathway:R-RNO-937039] IRAK1 recruits IKK complex - Rattus norvegicus [Reaction:R-RNO-166869] TRAF6 binds MEKK1 - Rattus norvegicus [Pathway:R-RNO-445989] TAK1-dependent IKK and NF-kappa-B activation - Rattus norvegicus [Pathway:R-RNO-450294] MAP kinase activation - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-166058
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166016] Toll Like Receptor 4 (TLR4) Cascade [Pathway:R-RNO-168179] Toll Like Receptor TLR1:TLR2 Cascade [Pathway:R-RNO-168188] Toll Like Receptor TLR6:TLR2 Cascade
(hasEncapsulatedEvent)	[Pathway:R-RNO-5686938] Regulation of TLR by endogenous ligand
(inferredTo)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane

© 2026 Reactome

Cite Us!