Reactome | IRAK2 mediated activation of TAK1 complex

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IRAK2 mediated activation of TAK1 complex Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224049
displayName	IRAK2 mediated activation of TAK1 complex
eventOf	[Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-936963] IRAK2 induces TRAF6 oligomerization - Rattus norvegicus [BlackBoxEvent:R-RNO-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Rattus norvegicus [Polymerisation:R-RNO-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Rattus norvegicus [Reaction:R-RNO-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Rattus norvegicus [Reaction:R-RNO-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IRAK2 mediated activation of TAK1 complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-937042
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Pathway:R-RNO-975871] MyD88 cascade initiated on plasma membrane
(inferredTo)	[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex

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