Reactome | TRAF6 binds MEKK1

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TRAF6 binds MEKK1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10117119
displayName	TRAF6 binds MEKK1
eventOf	[Pathway:R-RNO-975871] MyD88 cascade initiated on plasma membrane - Rattus norvegicus [Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-166869] TRAF6 binds MEKK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-166866] MAP3K1 [cytosol] [EntityWithAccessionedSequence:R-RNO-166366] Traf6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAF6 binds MEKK1
output	[Complex:R-RNO-166867] MEKK1:activated TRAF6 [cytosol]
regulatedBy	[Requirement:10117120] Requirement by 'ECSIT [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-166869
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Pathway:R-RNO-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [Pathway:R-RNO-975871] MyD88 cascade initiated on plasma membrane
(inferredTo)	[Reaction:R-HSA-166869] TRAF6 binds MEKK1