Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

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Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224127
displayName	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
eventOf	[Pathway:R-RNO-1234174] Cellular response to hypoxia - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:528641] cellular response to hypoxia
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A - Rattus norvegicus [Reaction:R-RNO-1234173] Cytosolic PHD2,3 hydroxylates proline residues on HIF3A - Rattus norvegicus [Reaction:R-RNO-1234181] Nuclear PHD1,3 hydroxylates proline residues on HIF1A - Rattus norvegicus [Reaction:R-RNO-1234165] Nuclear PHD1,3 hydroxylates proline residues on HIF3A - Rattus norvegicus [Reaction:R-RNO-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Rattus norvegicus [Reaction:R-RNO-1234169] Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Rattus norvegicus [Reaction:R-RNO-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Rattus norvegicus [Reaction:R-RNO-1234172] Nuclear VBC complex ubiquitinylates HIF-alpha - Rattus norvegicus [BlackBoxEvent:R-RNO-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Rattus norvegicus [BlackBoxEvent:R-RNO-1234159] Proteasome proteolyzes ub-HIF-alpha - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1234176
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1234174] Cellular response to hypoxia
(inferredTo)	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha