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Entries
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
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authored
[InstanceEdit:1234160] May, B, 2011-03-09
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1234178] May, B, 2011-03-18
crossReference
[DatabaseIdentifier:12325580] BioModels Database:BIOMD0000000300
dbId
1234176
displayName
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
edited
[InstanceEdit:1234160] May, B, 2011-03-09
eventOf
[Pathway:R-HSA-1234174] Cellular response to hypoxia - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:528641] cellular response to hypoxia
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-1234179] Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) - Homo sapiens
[Reaction:R-HSA-1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A - Homo sapiens
[Reaction:R-HSA-1234173] Cytosolic PHD2,3 hydroxylates proline residues on HIF3A - Homo sapiens
[Reaction:R-HSA-1234166] Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) - Homo sapiens
[Reaction:R-HSA-1234181] Nuclear PHD1,3 hydroxylates proline residues on HIF1A - Homo sapiens
[Reaction:R-HSA-1234165] Nuclear PHD1,3 hydroxylates proline residues on HIF3A - Homo sapiens
[Reaction:R-HSA-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Homo sapiens
[Reaction:R-HSA-1234169] Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Homo sapiens
[Reaction:R-HSA-1234163] Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha - Homo sapiens
[Reaction:R-HSA-1234172] Nuclear VBC complex ubiquitinylates HIF-alpha - Homo sapiens
[BlackBoxEvent:R-HSA-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Homo sapiens
[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1234003] A conserved family of prolyl-4-hydroxylases that modify HIF
[LiteratureReference:1234007] A gain-of-function mutation in the HIF2A gene in familial erythrocytosis
[LiteratureReference:1233948] Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
[LiteratureReference:1233984] Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
[LiteratureReference:1234017] Determination and comparison of specific activity of the HIF-prolyl hydroxylases
[LiteratureReference:1233982] Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
[LiteratureReference:1234067] Differential sensitivity of HIF hydroxylation sites to hypoxia and hydroxylase inhibitors
[LiteratureReference:1233945] Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline
[LiteratureReference:1233997] Expression and purification of catalytically active human PHD3 in Escherichia coli
[LiteratureReference:1233936] HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
[LiteratureReference:1233947] HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
[LiteratureReference:1234006] Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing
[LiteratureReference:1234031] Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
[LiteratureReference:392092] Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
orthologousEvent
[Pathway:R-CEL-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Caenorhabditis elegans
[Pathway:R-DME-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Drosophila melanogaster
[Pathway:R-GGA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Gallus gallus
[Pathway:R-XTR-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Xenopus tropicalis
[Pathway:R-DRE-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Danio rerio
[Pathway:R-SSC-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Sus scrofa
[Pathway:R-BTA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Bos taurus
[Pathway:R-CFA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Canis familiaris
[Pathway:R-RNO-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Rattus norvegicus
[Pathway:R-MMU-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Mus musculus
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1234176
summation
[Summation:1235006] HIF-alpha subunits, comprising HIF1A (Bruick and McKnight 20...
Referrals
(hasEvent)
[Pathway:R-HSA-1234174] Cellular response to hypoxia
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