Reactome | Cytosolic PHD2,3 hydroxylates proline residues on HIF1A

Schema > Reaction > Entries

Cytosolic PHD2,3 hydroxylates proline residues on HIF1A Show undefined attributes

catalystActivity	[CatalystActivity:10151712] peptidyl-proline 4-dioxygenase activity of PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151718
displayName	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
eventOf	[Pathway:R-RNO-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29406] 2OG [cytosol] [EntityWithAccessionedSequence:R-RNO-1234102] Hif1a [cytosol] 2 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
output	2 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] [EntityWithAccessionedSequence:R-RNO-1234131] Hif1a [cytosol] 2 × [SimpleEntity:R-ALL-29434] SUCCA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1234177
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
(precedingEvent)	[Reaction:R-RNO-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
(inferredTo)	[Reaction:R-HSA-1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A

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