Reactome | Cellular response to hypoxia

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Cellular response to hypoxia Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224129
displayName	Cellular response to hypoxia
eventOf	[Pathway:R-RNO-2262752] Cellular responses to stress - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:528641] cellular response to hypoxia
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) - Rattus norvegicus [Pathway:R-RNO-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Rattus norvegicus [Pathway:R-RNO-1234158] Regulation of gene expression by Hypoxia-inducible Factor - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-1234174] Cellular response to hypoxia - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1234174
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2262752] Cellular responses to stress
(hasEncapsulatedEvent)	[Pathway:R-RNO-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-1234174] Cellular response to hypoxia

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