Reactome | PXLP-K259-GOT1 transaminates 2-OG and L-Asp

Schema > Reaction > Entries

PXLP-K259-GOT1 transaminates 2-OG and L-Asp Show undefined attributes

catalystActivity	[CatalystActivity:9986417] L-aspartate:2-oxoglutarate aminotransferase activity of PXLP-K259-GOT1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9986430
displayName	PXLP-K259-GOT1 transaminates 2-OG and L-Asp
eventOf	[Pathway:R-MMU-8963693] Aspartate and asparagine metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8875623] SLC25A18,22 import L-Glu, H+ - Mus musculus [Reaction:R-MMU-9856871] MDH1 reduces OA - Mus musculus [Reaction:R-MMU-9861660] ME1 tetramer decarboxylates OA to PYR - Mus musculus [Reaction:R-MMU-70241] PCK1 phosphorylates OA to yield PEP - Mus musculus [Reaction:R-MMU-372448] SLC25A12,13 exchange L-Glu and L-Asp - Mus musculus
inferredFrom	[Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K259-GOT1 transaminates 2-OG and L-Asp 2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate
output	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-76213] OA [cytosol]
precedingEvent	[Reaction:R-MMU-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Mus musculus [Reaction:R-MMU-372448] SLC25A12,13 exchange L-Glu and L-Asp - Mus musculus [Reaction:R-MMU-376851] SLC25A11 exchanges 2-OG and MAL - Mus musculus [Reaction:R-MMU-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Mus musculus [Reaction:R-MMU-6797627] ASPG hydrolyses L-Asn to L-Asp - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-70592
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963693] Aspartate and asparagine metabolism [Pathway:R-MMU-9856872] Malate-aspartate shuttle
(precedingEvent)	[Reaction:R-MMU-372448] SLC25A12,13 exchange L-Glu and L-Asp [Reaction:R-MMU-8875623] SLC25A18,22 import L-Glu, H+ [Reaction:R-MMU-9856871] MDH1 reduces OA [Reaction:R-MMU-9861660] ME1 tetramer decarboxylates OA to PYR [Reaction:R-MMU-70241] PCK1 phosphorylates OA to yield PEP
(inferredTo)	[Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp