Reactome | ASPA deacetylates NAASP to acetate and L-aspartate

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ASPA deacetylates NAASP to acetate and L-aspartate Show undefined attributes

catalystActivity	[CatalystActivity:10063044] aspartoacylase activity of ASPA:Zn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10063046
displayName	ASPA deacetylates NAASP to acetate and L-aspartate
eventOf	[Pathway:R-MMU-8963693] Aspartate and asparagine metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs - Mus musculus [Reaction:R-MMU-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - Mus musculus [Reaction:R-MMU-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Mus musculus
inferredFrom	[Reaction:R-HSA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5693772] NAASP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ASPA deacetylates NAASP to acetate and L-aspartate H2O + N-acetyl-L-aspartate => acetate + L-aspartate
output	[SimpleEntity:R-ALL-29416] CH3COO- [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
precedingEvent	[Reaction:R-MMU-5693783] NAALADases hydrolyse NAAG - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5691507
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963693] Aspartate and asparagine metabolism
(precedingEvent)	[Reaction:R-MMU-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs [Reaction:R-MMU-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Reaction:R-MMU-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
(inferredTo)	[Reaction:R-HSA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate

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