Reactome | Activation of WASP and N-WASP by CDC42

Activation of WASP and N-WASP by CDC42

Stable Identifier

R-MMU-442572

Type

Reaction [binding]

Species

Mus musculus

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

The activation of WASP and N-WASP (WASL) by CDC42:GTP was demonstrated by mouse system-based experiments (Symons et al. 1996, Kolluri et al. 1996, Rohatgi et al. 1999, Park and Cox 2009)

Literature References

PubMed ID	Title	Journal	Year
10219243	The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly Rohatgi, R, Ma, L, Miki, H, Lopez, M, Kirchhausen, Tomas, Takenawa, T, Kirschner, MW	Cell	1999
8625410	Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization Symons, M, Derry, JM, Karlak, B, Jiang, S, Lemahieu, V, McCormick, F, Francke, U, Abo, A	Cell	1996
19741094	Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP Park, H, Cox, D	Mol Biol Cell	2009
8643625	Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42 Kolluri, R, Tolias, KF, Carpenter, CL, Rosen, FS, Kirchhausen, Tomas	Proc Natl Acad Sci U S A	1996