Reactome | TPCN1/2 transport lysosomal Ca2+ to cytosol

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TPCN1/2 transport lysosomal Ca2+ to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10046108] NAADP-sensitive calcium-release channel activity of TPCN1/2 [lysosomal membrane]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046110
displayName	TPCN1/2 transport lysosomal Ca2+ to cytosol
eventOf	[Pathway:R-MMU-2672351] Stimuli-sensing channels - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2685505] TPCN1/2 transport lysosomal Ca2+ to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-1606834] Ca2+ [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	TPCN1/2 transport lysosomal Ca2+ to cytosol
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-2730673] Positive regulation by 'NAADP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2685505
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2672351] Stimuli-sensing channels
(inferredTo)	[Reaction:R-HSA-2685505] TPCN1/2 transport lysosomal Ca2+ to cytosol

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