Reactome | TTYH2/3 transport cytosolic Cl- to extracellular region

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TTYH2/3 transport cytosolic Cl- to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10046470] chloride channel activity of TTYH2/3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046472
displayName	TTYH2/3 transport cytosolic Cl- to extracellular region
eventOf	[Pathway:R-MMU-2672351] Stimuli-sensing channels - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2744242] TTYH2/3 transport cytosolic Cl- to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-352022] Cl- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TTYH2/3 transport cytosolic Cl- to extracellular region
output	[SimpleEntity:R-ALL-188972] Cl- [extracellular region]
regulatedBy	[PositiveRegulation:R-HSA-2744259] Positive regulation by 'Ca2+ [cytosol]' [PositiveRegulation:10046097] Positive regulation by 'N-terminus CLCAs [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2744242
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2672351] Stimuli-sensing channels
(inferredTo)	[Reaction:R-HSA-2744242] TTYH2/3 transport cytosolic Cl- to extracellular region

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