Reactome | RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol

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RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10046560] calcium-induced calcium release activity of RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin [sarcoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:261378] sarcoplasmic reticulum lumen [Compartment:261659] sarcoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046562
displayName	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol
eventOf	[Pathway:R-MMU-5578775] Ion homeostasis - Mus musculus [Pathway:R-MMU-2672351] Stimuli-sensing channels - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2855020] RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-2855229] Ca2+ [sarcoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-8866468] Positive regulation by 'ATP [cytosol]' [PositiveRegulation:R-HSA-2744259] Positive regulation by 'Ca2+ [cytosol]' [PositiveRegulation:10015332] Positive regulation by 'SRI [sarcoplasmic reticulum membrane]' [NegativeRegulation:10015331] Negative regulation by 'CALM1 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2855020
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5578775] Ion homeostasis [Pathway:R-MMU-2672351] Stimuli-sensing channels
(inferredTo)	[Reaction:R-HSA-2855020] RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol

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