Reactome | Hydrolysis of PIP3 to PI(3,4)P2

Schema > Reaction > Entries

Hydrolysis of PIP3 to PI(3,4)P2 Show undefined attributes

catalystActivity	[CatalystActivity:10004401] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of INPP5D [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10004403
displayName	Hydrolysis of PIP3 to PI(3,4)P2
eventOf	[Pathway:R-MMU-202424] Downstream TCR signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-202164] Translocation of PDK1 to Plasma membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Hydrolysis of PIP3 to PI(3,4)P2
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-202237
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-MMU-202164] Translocation of PDK1 to Plasma membrane
(inferredTo)	[Reaction:R-HSA-202237] Hydrolysis of PIP3 to PI(3,4)P2

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