Reactome | Hydrolysis of PIP3 to PI(3,4)P2

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Hydrolysis of PIP3 to PI(3,4)P2 Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202259] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of INPP5D [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202237
displayName	Hydrolysis of PIP3 to PI(3,4)P2
eventOf	[Pathway:R-HSA-202424] Downstream TCR signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-202164] Translocation of PDK1 to Plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202374] Structure, function, and biology of SHIP proteins [LiteratureReference:202169] Regulation of the immune response by SHIP
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Hydrolysis of PIP3 to PI(3,4)P2
orthologousEvent	[Reaction:R-GGA-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Gallus gallus [Reaction:R-XTR-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Xenopus tropicalis [Reaction:R-SSC-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Sus scrofa [Reaction:R-BTA-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Bos taurus [Reaction:R-CFA-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Canis familiaris [Reaction:R-RNO-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Rattus norvegicus [Reaction:R-MMU-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202237
summation	[Summation:202332] After the generation of PIP3 by PI3K, a part of it is furthe...

Referrals

(hasEvent)	[Pathway:R-HSA-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-HSA-202164] Translocation of PDK1 to Plasma membrane