Reactome | Translocation of PDK1 to Plasma membrane

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Translocation of PDK1 to Plasma membrane Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10004209
displayName	Translocation of PDK1 to Plasma membrane
eventOf	[Pathway:R-MMU-2730905] Role of LAT2/NTAL/LAB on calcium mobilization - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-202328] Translocation of PKC theta to plasma membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-202164] Translocation of PDK1 to Plasma membrane - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-202210] PDPK1 [cytosol] [DefinedSet:R-ALL-202277] PIP3, PI(3,4)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Translocation of PDK1 to Plasma membrane
output	[Complex:R-MMU-202311] PDK1:PIP2,PIP3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Mus musculus [Reaction:R-MMU-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-202164
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2730905] Role of LAT2/NTAL/LAB on calcium mobilization [Pathway:R-MMU-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-MMU-202328] Translocation of PKC theta to plasma membrane
(inferredTo)	[Reaction:R-HSA-202164] Translocation of PDK1 to Plasma membrane