Reactome | Downstream TCR signaling

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Downstream TCR signaling Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099759
displayName	Downstream TCR signaling
eventOf	[Pathway:R-MMU-202403] TCR signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-202203] Recruitment of PI3K to plasma membrane - Mus musculus [Reaction:R-MMU-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-202237] Hydrolysis of PIP3 to PI(3,4)P2 - Mus musculus [Reaction:R-MMU-199456] PTEN dephosphorylates PIP3 - Mus musculus [Reaction:R-MMU-202164] Translocation of PDK1 to Plasma membrane - Mus musculus [Reaction:R-MMU-202328] Translocation of PKC theta to plasma membrane - Mus musculus [Reaction:R-MMU-202307] Change of PKC theta conformation - Mus musculus [Reaction:R-MMU-202222] Phosphorylation of PKC theta - Mus musculus [Reaction:R-MMU-202394] Translocation of CARMA1 to Plasma membrane - Mus musculus [Reaction:R-MMU-202437] Phosphorylation of CARMA1 - Mus musculus [Reaction:R-MMU-202443] Oligomerization of CARMA1 - Mus musculus [Reaction:R-MMU-202466] Interaction of Bcl10 to CARMA1 - Mus musculus [Reaction:R-MMU-202459] Phosphorylation of Bcl10 - Mus musculus [Reaction:R-MMU-202489] Oligomerization of Bcl10 - Mus musculus [Reaction:R-MMU-202478] Interaction and oligomerization of MALT1 to Bcl10 - Mus musculus [Reaction:R-MMU-202472] Translocation of TRAF6 to CBM complex - Mus musculus [Reaction:R-MMU-202453] Auto-ubiquitination of TRAF6 - Mus musculus [Reaction:R-MMU-202510] Activation of TAK1-TAB2 complex - Mus musculus [Reaction:R-MMU-202500] Activation of IKK complex - Mus musculus [BlackBoxEvent:R-MMU-202534] Ubiquitination of NEMO by TRAF6 - Mus musculus [Reaction:R-MMU-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Mus musculus [BlackBoxEvent:R-MMU-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex - Mus musculus [BlackBoxEvent:R-MMU-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Mus musculus [BlackBoxEvent:R-MMU-2730894] NFKB1:RELA translocates from the cytosol to the nucleus - Mus musculus
inferredFrom	[Pathway:R-HSA-202424] Downstream TCR signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Downstream TCR signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-202424
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-202403] TCR signaling
(inferredTo)	[Pathway:R-HSA-202424] Downstream TCR signaling

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