Reactome | NMRK2 phosphorylates NR to yield NMN

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NMRK2 phosphorylates NR to yield NMN Show undefined attributes

catalystActivity	[CatalystActivity:10078718] ribosylnicotinamide kinase activity of NMRK2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10078720
displayName	NMRK2 phosphorylates NR to yield NMN
eventOf	[Pathway:R-MMU-196807] Nicotinate metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - Mus musculus
inferredFrom	[Reaction:R-HSA-8869627] NMRK2 phosphorylates NR to yield NMN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-8869377] NR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NMRK2 phosphorylates NR to yield NMN beta-nicotinamide D-riboside + ATP => beta-nicotinamide D-ribonucleotide + ADP + H(+) NR + ATP(4-) => NMN + ADP(3-) + H+
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-8869353] NMN [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8869627
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-MMU-8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+
(inferredTo)	[Reaction:R-HSA-8869627] NMRK2 phosphorylates NR to yield NMN

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