Reactome | NAMPT transfers PRIB to NAM to form NAMN

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NAMPT transfers PRIB to NAM to form NAMN Show undefined attributes

catalystActivity	[CatalystActivity:10002325] nicotinamide phosphoribosyltransferase activity of NAMPT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002327
displayName	NAMPT transfers PRIB to NAM to form NAMN
eventOf	[Pathway:R-MMU-196807] Nicotinate metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus [Reaction:R-MMU-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus [Reaction:R-MMU-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus
inferredFrom	[Reaction:R-HSA-197250] NAMPT transfers PRIB to NAM to form NAMN - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-197277] NAM [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NAMPT transfers PRIB to NAM to form NAMN 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+) => beta-nicotinamide D-ribonucleotide + diphosphate Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN)
output	[SimpleEntity:R-ALL-8869359] NAMN [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-197250
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-MMU-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD [Reaction:R-MMU-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD [Reaction:R-MMU-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
(inferredTo)	[Reaction:R-HSA-197250] NAMPT transfers PRIB to NAM to form NAMN

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