Reactome | CD38 hydrolyses NAD+ to NAM and ADP-ribose

Schema > Reaction > Entries

CD38 hydrolyses NAD+ to NAM and ADP-ribose Show undefined attributes

catalystActivity	[CatalystActivity:10080950] NAD+ nucleosidase activity, cyclic ADP-ribose generating of CD38 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10080952
displayName	CD38 hydrolyses NAD+ to NAM and ADP-ribose
eventOf	[Pathway:R-MMU-196807] Nicotinate metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8938076] CD38 hydrolyses NAD+ to NAM and ADP-ribose - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-352330] NAD+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	CD38 hydrolyses NAD+ to NAM and ADP-ribose NAD(+) + H2O => ADP-D-ribose + nicotinamide + H(+)
output	[SimpleEntity:R-ALL-8870342] ADP-ribose [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-8870343] NAM [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8938076
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-8938076] CD38 hydrolyses NAD+ to NAM and ADP-ribose

Cite Us!