Reactome | Phospholipase C-gamma1 binds to the activated EGF receptor

Schema > Reaction > Entries

Phospholipase C-gamma1 binds to the activated EGF receptor Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10007141
displayName	Phospholipase C-gamma1 binds to the activated EGF receptor
eventOf	[Pathway:R-MMU-212718] EGFR interacts with phospholipase C-gamma - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-212710] EGFR activates PLC-gamma1 by phosphorylation - Mus musculus
inferredFrom	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens
input	[Complex:R-MMU-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-MMU-202320] PLCG1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phospholipase C-gamma1 binds to the activated EGF receptor
output	[Complex:R-MMU-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-177937] Phosphorylation of EGFR by SRC kinase - Mus musculus [Reaction:R-MMU-177934] EGFR autophosphorylation - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-212706
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-212718] EGFR interacts with phospholipase C-gamma
(precedingEvent)	[Reaction:R-MMU-212710] EGFR activates PLC-gamma1 by phosphorylation
(inferredTo)	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor

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