Reactome | SHC1 binds to the phosphorylated EGF receptor:ligand complex

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SHC1 binds to the phosphorylated EGF receptor:ligand complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9999726
displayName	SHC1 binds to the phosphorylated EGF receptor:ligand complex
eventOf	[Pathway:R-MMU-180336] SHC1 events in EGFR signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-177933] SHC1 phosphorylation by phosphorylated EGFR - Mus musculus
inferredFrom	[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Homo sapiens
input	[Complex:R-MMU-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-MMU-74680] Shc1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SHC1 binds to the phosphorylated EGF receptor:ligand complex
output	[Complex:R-MMU-9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-177934] EGFR autophosphorylation - Mus musculus [Reaction:R-MMU-177937] Phosphorylation of EGFR by SRC kinase - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-177925
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-180336] SHC1 events in EGFR signaling
(precedingEvent)	[Reaction:R-MMU-177933] SHC1 phosphorylation by phosphorylated EGFR
(inferredTo)	[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex

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