Reactome | Signaling by EGFR

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Signaling by EGFR Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098863
displayName	Signaling by EGFR
eventOf	[Pathway:R-MMU-9006934] Signaling by Receptor Tyrosine Kinases - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8092] epidermal growth factor receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-9674531] AAMP binds EGFR - Mus musculus [Reaction:R-MMU-9851407] FAM83B, (FAM83A, FAM83D) bind EGFR - Mus musculus [Reaction:R-MMU-177942] EGFR binds EGF ligand - Mus musculus [Reaction:R-MMU-177922] EGFR dimerization - Mus musculus [Reaction:R-MMU-177934] EGFR autophosphorylation - Mus musculus [Reaction:R-MMU-177937] Phosphorylation of EGFR by SRC kinase - Mus musculus [Pathway:R-MMU-212718] EGFR interacts with phospholipase C-gamma - Mus musculus [Pathway:R-MMU-179812] GRB2 events in EGFR signaling - Mus musculus [Pathway:R-MMU-180336] SHC1 events in EGFR signaling - Mus musculus [Pathway:R-MMU-180292] GAB1 signalosome - Mus musculus [Pathway:R-MMU-182971] EGFR downregulation - Mus musculus
inferredFrom	[Pathway:R-HSA-177929] Signaling by EGFR - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by EGFR Epidermal Growth Factor Receptor (EGFR) signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-177929
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)	[Pathway:R-MMU-1257604] PIP3 activates AKT signaling [Pathway:R-MMU-8848021] Signaling by PTK6 [Pathway:R-MMU-5673001] RAF/MAP kinase cascade [Pathway:R-MMU-9009391] Extra-nuclear estrogen signaling
(inferredTo)	[Pathway:R-HSA-177929] Signaling by EGFR

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