Reactome | Calcineurin dephosphorylates NFATC1,2,3

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Calcineurin dephosphorylates NFATC1,2,3 Show undefined attributes

authored	[InstanceEdit:2025992] May, B, 2011-12-11
catalystActivity	[CatalystActivity:2025922] calcium-dependent protein serine/threonine phosphatase activity of Calcineurin:p-NFATC1,2,3 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:2025849] May, B, 2011-12-20
dbId	2025882
displayName	Calcineurin dephosphorylates NFATC1,2,3
edited	[InstanceEdit:2025992] May, B, 2011-12-11
eventOf	[Pathway:R-HSA-2025928] Calcineurin activates NFAT - Homo sapiens
followingEvent	[Reaction:R-HSA-9976381] GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene - Homo sapiens [Reaction:R-HSA-9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) - Homo sapiens [Reaction:R-HSA-9976129] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, and MAF bind the IL4 gene - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-2025936] Calcineurin Dephosphorylates Nfatc2 - Mus musculus
input	[Complex:R-HSA-2025899] Calcineurin:p-NFATC1,2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2025847] Evidence that calcineurin is rate-limiting for primary human lymphocyte activation [LiteratureReference:2025945] Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp [LiteratureReference:2025874] Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 [LiteratureReference:2025907] Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity [LiteratureReference:2025911] Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells [LiteratureReference:2025987] Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Calcineurin dephosphorylates NFATC1,2,3
output	[DefinedSet:R-HSA-2025852] Dephosphorylated NFATC1,2,3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2025890] Calcineurin binds NFATC1,2,3 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-2026015] Negative regulation by 'Cyclophilin A:Cyclosporin A [cytosol]' [NegativeRegulation:R-HSA-2026021] Negative regulation by 'FKBP1A:tacrolimus [cytosol]'
regulationReference	[RegulationReference:9642060] Negative regulation by 'Cyclophilin A:Cyclosporin A [cytosol]' Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes [RegulationReference:9642772] Negative regulation by 'FKBP1A:tacrolimus [cytosol]' Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2025882
summation	[Summation:2025978] As inferred from mouse (Okamura et al. 2000), calcineurin de...

Referrals

(precedingEvent)	[Reaction:R-HSA-9976381] GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene [Reaction:R-HSA-9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Reaction:R-HSA-9976129] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, and MAF bind the IL4 gene
(hasEvent)	[Pathway:R-HSA-2025928] Calcineurin activates NFAT
(inferredTo)	[BlackBoxEvent:R-MMU-2025936] Calcineurin Dephosphorylates Nfatc2

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