Reactome | NEK11 phosphorylates CDC25A

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NEK11 phosphorylates CDC25A Show undefined attributes

catalystActivity	[CatalystActivity:11048403] protein serine/threonine kinase activity of p-S273-NEK11 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11048405
displayName	NEK11 phosphorylates CDC25A
eventOf	[Pathway:R-DDI-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-9943676] NEK11 phosphorylates CDC25A - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-143488] phospho-cdc25 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEK11 phosphorylates CDC25A
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-9943711] phospho-cdc25 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-DDI-9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A - Dictyostelium discoideum [Reaction:R-DDI-9943662] CHEK1 phosphorylates NEK11 - Dictyostelium discoideum [Reaction:R-DDI-9943675] GSK3B phosphorylates CDC25A - Dictyostelium discoideum [Reaction:R-DDI-69604] Phosphorylation of CDC25A by CHEK1 - Dictyostelium discoideum [Reaction:R-DDI-9942578] Phosphorylation of CDC25A by p38 MAPK - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9943676
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
(precedingEvent)	[Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A
(inferredTo)	[Reaction:R-HSA-9943676] NEK11 phosphorylates CDC25A