Reactome | Formation of the embryonic stem cell BAF (esBAF) complex

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Formation of the embryonic stem cell BAF (esBAF) complex Show undefined attributes

authored	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
created	[InstanceEdit:9933945] Rothfels, Karen, 2025-01-05
dbId	9933946
displayName	Formation of the embryonic stem cell BAF (esBAF) complex
edited	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
eventOf	[Pathway:R-HSA-9932451] SWI/SNF chromatin remodelers - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9934027] SMARCC1 and SMARCC2 bind SMARCD1 - Homo sapiens [Reaction:R-HSA-9934026] SMARCE1 and SMARCB1 bind SMARCC1:SMARCC2 dimer:SMARCD1 - Homo sapiens [Reaction:R-HSA-9934028] ARID1A binds SMARCC1:SMARCC2 dimer:SMARCD1:SMARCE1:SMARCB1 - Homo sapiens [Reaction:R-HSA-9934022] DPF2, PHF10 bind SMARCC1:SMARCC2 dimer:SMARD1:ARID1A - Homo sapiens [Reaction:R-HSA-9934024] SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9933219] An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network [LiteratureReference:9932374] An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency [LiteratureReference:9933930] Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells [LiteratureReference:9933220] Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics [LiteratureReference:9933218] COMPASS and SWI/SNF complexes in development and disease [LiteratureReference:9933957] GBAF, a small BAF sub-complex with big implications: a systematic review [LiteratureReference:9933992] MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs [LiteratureReference:9933223] Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy [LiteratureReference:9933968] esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function [LiteratureReference:9932366] A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms [LiteratureReference:9727476] Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
maxDepth	2
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Formation of the embryonic stem cell BAF (esBAF) complex
orthologousEvent	[Pathway:R-SPO-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Schizosaccharomyces pombe [Pathway:R-DDI-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Dictyostelium discoideum [Pathway:R-CEL-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Caenorhabditis elegans [Pathway:R-DME-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Drosophila melanogaster [Pathway:R-GGA-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Gallus gallus [Pathway:R-DRE-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Danio rerio [Pathway:R-SSC-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Sus scrofa [Pathway:R-BTA-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Bos taurus [Pathway:R-CFA-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Canis familiaris [Pathway:R-RNO-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Rattus norvegicus [Pathway:R-MMU-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938992] Dykhuizen, Emily C, 2025-02-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9933946
summation	[Summation:9933997] A distinct BAF complex has been identified in mouse and huma...

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[Pathway:R-HSA-9932451] SWI/SNF chromatin remodelers

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