Reactome | SWI/SNF chromatin remodelers

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SWI/SNF chromatin remodelers Show undefined attributes

authored	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
created	[InstanceEdit:9932445] Rothfels, Karen, 2024-12-19
dbId	9932451
displayName	SWI/SNF chromatin remodelers
edited	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
eventOf	[Pathway:R-HSA-9932444] ATP-dependent chromatin remodelers - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9933937] Formation of the canonical BAF (cBAF) complex - Homo sapiens [Pathway:R-HSA-9933939] Formation of the polybromo-BAF (pBAF) complex - Homo sapiens [Pathway:R-HSA-9933947] Formation of the non-canonical BAF (ncBAF) complex - Homo sapiens [Pathway:R-HSA-9933946] Formation of the embryonic stem cell BAF (esBAF) complex - Homo sapiens [Pathway:R-HSA-9934037] Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9933234] Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes [LiteratureReference:9932793] The BAF complex enhances transcription through interaction with H3K56ac in the histone globular domain [LiteratureReference:9933217] Energy-driven genome regulation by ATP-dependent chromatin remodellers [LiteratureReference:9932384] Structure of nucleosome-bound human BAF complex [LiteratureReference:9932366] A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms [LiteratureReference:9727476] Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes [LiteratureReference:9932752] Structure of nucleosome-bound human PBAF complex [LiteratureReference:9932803] Structure of human chromatin-remodelling PBAF complex bound to a nucleosome [LiteratureReference:9932392] Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes [LiteratureReference:9932772] A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation [LiteratureReference:9932762] An essential switch in subunit composition of a chromatin remodeling complex during neural development [LiteratureReference:9932374] An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency [LiteratureReference:9933219] An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network [LiteratureReference:9933930] Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells [LiteratureReference:9933218] COMPASS and SWI/SNF complexes in development and disease [LiteratureReference:9933223] Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy [LiteratureReference:9933220] Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics [LiteratureReference:9933229] The SWI/SNF complex in cancer - biology, biomarkers and therapy [LiteratureReference:9933224] SWI/SNF complexes and cancers
maxDepth	3
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	SWI/SNF chromatin remodelers
orthologousEvent	[Pathway:R-MMU-9932451] SWI/SNF chromatin remodelers - Mus musculus [Pathway:R-RNO-9932451] SWI/SNF chromatin remodelers - Rattus norvegicus [Pathway:R-CFA-9932451] SWI/SNF chromatin remodelers - Canis familiaris [Pathway:R-BTA-9932451] SWI/SNF chromatin remodelers - Bos taurus [Pathway:R-SSC-9932451] SWI/SNF chromatin remodelers - Sus scrofa [Pathway:R-DRE-9932451] SWI/SNF chromatin remodelers - Danio rerio [Pathway:R-XTR-9932451] SWI/SNF chromatin remodelers - Xenopus tropicalis [Pathway:R-GGA-9932451] SWI/SNF chromatin remodelers - Gallus gallus [Pathway:R-DME-9932451] SWI/SNF chromatin remodelers - Drosophila melanogaster [Pathway:R-CEL-9932451] SWI/SNF chromatin remodelers - Caenorhabditis elegans [Pathway:R-DDI-9932451] SWI/SNF chromatin remodelers - Dictyostelium discoideum [Pathway:R-SPO-9932451] SWI/SNF chromatin remodelers - Schizosaccharomyces pombe
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938992] Dykhuizen, Emily C, 2025-02-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9932451
summation	[Summation:9933243] Mammalian SWI/SNF complexes are ATP-dependent chromatin remo...

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[Pathway:R-HSA-9932444] ATP-dependent chromatin remodelers

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