Reactome | Formation of the embryonic stem cell BAF (esBAF) complex

Formation of the embryonic stem cell BAF (esBAF) complex

Stable Identifier

R-HSA-9933946

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Formation of the embryonic stem cell BAF (esBAF) complex

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A distinct BAF complex has been identified in mouse and human embryonic stem cells (esBAF) (Ho, Jothi et al, 2009, Ho, Ronan et al, 2009; Zhang et al, 2014; reviewed in Kadoch and Crabtree, 2015; Cenik and Shilatifard, 2021; Innis and Cabot, 2020). esBAF is characterized by the presence of SMARCA4/BRG1 to the exclusion of SMARCA2/BRM and SMARCD1/BAF60A. Where mouse esBAF uses only SMARCC1 (BAF155), human esBAF appears to contain both SMARCC1 (BAF155) and SMARCC2 (BAF170) (Ho, Ronan et al, 2009; Ho, Jothi et al, 2009; Zhang et al, 2014; Wade et al, 2015). esBAF also contains subunits BCL11A/B (Kadoch et al, 2013; reviewed in Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021).
esBAF colocalizes with each of the pluripotency factors, and overexpression of esBAF subunits induces pluripotency in fibroblasts (Ho, Ronan et al, 2009; Ho et al, 2011).
As the assembly of human esBAF has not been examined in detail, this pathway is based on the modular assembly of cBAF, pBAF and ncBAF (Mashtalir et al, 2018; Mashtalir et al, 2020).

Literature References

PubMed ID	Title	Journal	Year
26119756	MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs Wade, SL, Langer, LF, Ward, JM, Archer, TK	Stem Cells	2015
25241744	Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells Zhang, X, Li, B, Li, W, Ma, L, Zheng, D, Li, L, Yang, W, Chu, M, Chen, W, Mailman, RB, Zhu, J, Fan, G, Archer, TK, Wang, Y	Stem Cell Reports	2014
33053319	A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms Mashtalir, N, Suzuki, H, Farrell, DP, Sankar, A, Luo, J, Filipovski, M, D'Avino, AR, St Pierre, R, Valencia, AM, Onikubo, T, Roeder, RG, Han, Y, He, Y, Ranish, JA, Dimaio, F, Walz, T, Kadoch, C	Cell	2020
21785422	esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function Ho, L, Miller, EL, Ronan, JL, Ho, WQ, Jothi, R, Crabtree, GR	Nat Cell Biol	2011
32958894	COMPASS and SWI/SNF complexes in development and disease Cenik, BK, Shilatifard, A	Nat Rev Genet	2021
19279218	An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network Ho, L, Jothi, R, Ronan, JL, Cui, K, Zhao, K, Crabtree, GR	Proc Natl Acad Sci U S A	2009
26601204	Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics Kadoch, C, Crabtree, GR	Sci Adv	2015
33143733	GBAF, a small BAF sub-complex with big implications: a systematic review Innis, SM, Cabot, B	Epigenetics Chromatin	2020
19279220	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency Ho, L, Ronan, JL, Wu, J, Staahl, BT, Chen, L, Kuo, A, Lessard, J, Nesvizhskii, AI, Ranish, J, Crabtree, GR	Proc Natl Acad Sci U S A	2009
30343899	Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes Mashtalir, N, D'Avino, AR, Michel, BC, Luo, J, Pan, J, Otto, JE, Zullow, HJ, McKenzie, ZM, Kubiak, RL, St Pierre, R, Valencia, AM, Poynter, SJ, Cassel, SH, Ranish, JA, Kadoch, C	Cell	2018
23644491	Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy Kadoch, C, Hargreaves, DC, Hodges, C, Elias, L, Ho, L, Ranish, J, Crabtree, GR	Nat Genet	2013