Reactome | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)

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AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
created	[InstanceEdit:9931260] Tiwari, Krishna, 2024-12-11
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	9931269
displayName	AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9909615] Regulation of PD-L1(CD274) Post-translational modification - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9931292] AMPK phosphorylates CD274 - Homo sapiens [Reaction:R-HSA-9931313] p-S195-CD274 binds ERAD complex - Homo sapiens [Reaction:R-HSA-9931298] Ubiquitination of CD274 by ERAD complex - Homo sapiens [Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Homo sapiens [Reaction:R-HSA-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935388] Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 [LiteratureReference:9935371] Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
orthologousEvent	[Pathway:R-CEL-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Caenorhabditis elegans [Pathway:R-GGA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Gallus gallus [Pathway:R-XTR-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Xenopus tropicalis [Pathway:R-DRE-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Danio rerio [Pathway:R-SSC-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Sus scrofa [Pathway:R-BTA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Bos taurus [Pathway:R-CFA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Canis familiaris [Pathway:R-RNO-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Rattus norvegicus [Pathway:R-MMU-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Mus musculus
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9931269
summation	[Summation:9938220] Adenosine monophosphate (AMP)-activated protein kinase (AMPK...

Referrals

(hasEvent)

[Pathway:R-HSA-9909615] Regulation of PD-L1(CD274) Post-translational modification