Reactome | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)

Schema > Pathway > Entries

AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225507
displayName	AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
eventOf	[Pathway:R-RNO-9909615] Regulation of PD-L1(CD274) Post-translational modification - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9931292] AMPK phosphorylates CD274 - Rattus norvegicus [Reaction:R-RNO-9931313] p-S195-CD274 binds ERAD complex - Rattus norvegicus [Reaction:R-RNO-9931298] Ubiquitination of CD274 by ERAD complex - Rattus norvegicus [Reaction:R-RNO-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Rattus norvegicus [Reaction:R-RNO-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9931269
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9909615] Regulation of PD-L1(CD274) Post-translational modification
(inferredTo)	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)

© 2026 Reactome

Cite Us!