Reactome | AMPK phosphorylates CD274

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AMPK phosphorylates CD274 Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
catalystActivity	[CatalystActivity:9931277] protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9931260] Tiwari, Krishna, 2024-12-11
dbId	9931292
displayName	AMPK phosphorylates CD274
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Homo sapiens
followingEvent	[Reaction:R-HSA-9931313] p-S195-CD274 binds ERAD complex - Homo sapiens
input	[SimpleEntity:R-ALL-8931885] ATP [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-9930703] CD274 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935388] Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 [LiteratureReference:9935371] Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	AMPK phosphorylates CD274
orthologousEvent	[Reaction:R-GGA-9931292] AMPK phosphorylates CD274 - Gallus gallus [Reaction:R-SSC-9931292] AMPK phosphorylates CD274 - Sus scrofa [Reaction:R-BTA-9931292] AMPK phosphorylates CD274 - Bos taurus [Reaction:R-CFA-9931292] AMPK phosphorylates CD274 - Canis familiaris [Reaction:R-RNO-9931292] AMPK phosphorylates CD274 - Rattus norvegicus [Reaction:R-MMU-9931292] AMPK phosphorylates CD274 - Mus musculus
output	[SimpleEntity:R-ALL-8931884] ADP [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-9931301] p-S195-CD274 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9925190] CD274 translation - Homo sapiens
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931292
summation	[Summation:9937966] AMP-activated protein kinase (AMPK), activated in response t...

Referrals

(hasEvent)	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
(precedingEvent)	[Reaction:R-HSA-9931313] p-S195-CD274 binds ERAD complex