Reactome | Ubiquitination of CD274 by ERAD complex

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Ubiquitination of CD274 by ERAD complex Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
catalystActivity	[CatalystActivity:9931282] ubiquitin protein ligase activity of p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9931260] Tiwari, Krishna, 2024-12-11
dbId	9931298
displayName	Ubiquitination of CD274 by ERAD complex
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Homo sapiens
followingEvent	[Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Homo sapiens
input	[Complex:R-HSA-9931263] p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] [DefinedSet:R-HSA-8943136] Ub [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935388] Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Ubiquitination of CD274 by ERAD complex
orthologousEvent	[Reaction:R-CEL-9931298] Ubiquitination of CD274 by ERAD complex - Caenorhabditis elegans [Reaction:R-GGA-9931298] Ubiquitination of CD274 by ERAD complex - Gallus gallus [Reaction:R-XTR-9931298] Ubiquitination of CD274 by ERAD complex - Xenopus tropicalis [Reaction:R-DRE-9931298] Ubiquitination of CD274 by ERAD complex - Danio rerio [Reaction:R-SSC-9931298] Ubiquitination of CD274 by ERAD complex - Sus scrofa [Reaction:R-BTA-9931298] Ubiquitination of CD274 by ERAD complex - Bos taurus [Reaction:R-CFA-9931298] Ubiquitination of CD274 by ERAD complex - Canis familiaris [Reaction:R-RNO-9931298] Ubiquitination of CD274 by ERAD complex - Rattus norvegicus [Reaction:R-MMU-9931298] Ubiquitination of CD274 by ERAD complex - Mus musculus
output	[Complex:R-HSA-9931312] Poly-Ub-p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9931313] p-S195-CD274 binds ERAD complex - Homo sapiens
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931298
summation	[Summation:9937967] The ERAD complex consists of various components for substrat...

Referrals

(precedingEvent)	[Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol
(hasEvent)	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)