Reactome | Active transport of ubiquitinated CD274 from ER to cytosol

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Active transport of ubiquitinated CD274 from ER to cytosol Show undefined attributes

category	dissociation
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10326920
displayName	Active transport of ubiquitinated CD274 from ER to cytosol
eventOf	[Pathway:R-CFA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Canis familiaris
inferredFrom	[Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-8931885] ATP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [Complex:R-CFA-9931312] Poly-Ub-p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active transport of ubiquitinated CD274 from ER to cytosol
output	[SimpleEntity:R-ALL-8931884] ADP [endoplasmic reticulum lumen] [Complex:R-CFA-8866531] ERAD complex [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen] [Complex:R-CFA-9931275] polyUb-p-S195-CD274 [cytosol]
precedingEvent	[Reaction:R-CFA-9931298] Ubiquitination of CD274 by ERAD complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9931264
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
(precedingEvent)	[Reaction:R-CFA-9931314] Proteasomal degradation of polyUb-p-S195-CD274
(inferredTo)	[Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol