Reactome | Hbp cis-autocleaves

Schema > Reaction > Entries

Hbp cis-autocleaves Show undefined attributes

authored	[InstanceEdit:9926160] Stephan, Ralf, 2024-10-31
catalystActivity	[CatalystActivity:9926992] serine-type endopeptidase activity of Hbp [cell outer membrane]
category	transition
compartment	[Compartment:20798] cell outer membrane
created	[InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113 [DatabaseIdentifier:9961777] UniProt:Q9EZE7 [DatabaseIdentifier:9961778] UniProt:Q8FDW4 [DatabaseIdentifier:9961774] UniProt:Q7BSW5 [DatabaseIdentifier:9961773] UniProt:Q7BS42 [DatabaseIdentifier:9961775] UniProt:Q9XD84
dbId	9926963
disease	[Disease:3134792] bacterial infectious disease
displayName	Hbp cis-autocleaves
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9926936] EspC(54-1018) cleaves hemoglobin - Homo sapiens [BlackBoxEvent:R-HSA-9927009] Hbp(53-1100) cleaves hemoglobin - Homo sapiens
input	[SimpleEntity:R-ALL-9926997] H2O [periplasmic space] [EntityWithAccessionedSequence:R-ECO-9926950] Hbp [cell outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9927036] Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence [LiteratureReference:9926979] Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1 [LiteratureReference:9927032] EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC), displays protease activity on human hemoglobin [LiteratureReference:9927019] Serine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream [LiteratureReference:9926930] Phylogenetic Classification and Functional Review of Autotransporters
maxDepth	1
modified	[InstanceEdit:9971731] Matthews, Lisa, 2025-11-10
name	Hbp cis-autocleaves
output	[EntityWithAccessionedSequence:R-ECO-9927035] Hbp(1101-1377) [cell outer membrane] [EntityWithAccessionedSequence:R-ECO-9926999] Hbp(53-1100) [extracellular region]
precedingEvent	[Reaction:R-HSA-9926981] Bam complex inserts Hbp into outer membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9971594] D'Eustachio, Peter, 2025-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9926963
summation	[Summation:9926931] Serine protease autotransporters of Enterobacteriaceae (SPAT...
updateTrackers	[UpdateTracker:9964640] Update Tracker - [Reaction:9926963] Hbp cis-autocleaves - v94:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9964640] Update Tracker - [Reaction:9926963] Hbp cis-autocleaves - v94:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-9760173] Secretion of toxins
(precedingEvent)	[BlackBoxEvent:R-HSA-9926936] EspC(54-1018) cleaves hemoglobin [BlackBoxEvent:R-HSA-9927009] Hbp(53-1100) cleaves hemoglobin