Hbp cis-autocleaves

Stable Identifier
R-HSA-9926963
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
cell outer membrane
ReviewStatus
5/5
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Hbp cis-autocleaves
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Serine protease autotransporters of Enterobacteriaceae (SPATEs) like Hbp transport their protease domain through their pore domain and cleave it in cis, releasing it to extracellular space (Otto et al., 1998; Drago-Serrano et al., 2006; reviewed in Ruiz-Peres & Nataro, 2020; Clarke et al., 2022). SPATE expression is prevalent in extraintestinal E.coli (ExPEC) strains where the released proteases are responsible for tissue damage and cleavage of molecules of the complement system, which is a key feature for the establishment of infection in the bloodstream (Freire et al., 2020).
Literature References
PubMed ID Title Journal Year
17107418 EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC), displays protease activity on human hemoglobin

Drago-Serrano, ME, Parra, SG, Manjarrez-Hernández, HA

FEMS Microbiol Lett 2006
31965549 Serine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream

Freire, CA, Santos, ACM, Pignatari, AC, Silva, RM, Elias, WP

Braz J Microbiol 2020
23689588 Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence

Ruiz-Perez, F, Nataro, JP

Cell Mol Life Sci 2014
35860281 Phylogenetic Classification and Functional Review of Autotransporters

Clarke, KR, Hor, L, Pilapitiya, A, Luirink, J, Paxman, JJ, Heras, B

Front Immunol 2022
9743528 Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1

Otto, BR, van Dooren, SJ, Nuijens, JH, Luirink, J, Oudega, B

J Exp Med 1998
Participants
Input
Output
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Catalyst Activity

serine-type endopeptidase activity of Hbp [cell outer membrane]

Physical Entity
Hbp [cell outer membrane] (Escherichia coli)
Activity
serine-type endopeptidase activity (GO:0004252)
Disease
Cross References
UniProt
Mondo
Authored
Stephan, R  (2024-10-31)
Reviewed
D'Eustachio, P  (2025-11-07)
Created
Stephan, R  (2024-11-04)
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