Reactome | Bam complex inserts Hbp into outer membrane

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Bam complex inserts Hbp into outer membrane Show undefined attributes

authored	[InstanceEdit:9926160] Stephan, Ralf, 2024-10-31
catalystActivity	[CatalystActivity:9926996] membrane insertase activity of Bam complex [cell outer membrane]
category	transition
compartment	[Compartment:20798] cell outer membrane [Compartment:1222638] periplasmic space
created	[InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113 [DatabaseIdentifier:9961777] UniProt:Q9EZE7 [DatabaseIdentifier:9961778] UniProt:Q8FDW4 [DatabaseIdentifier:9961774] UniProt:Q7BSW5 [DatabaseIdentifier:9961773] UniProt:Q7BS42 [DatabaseIdentifier:9961775] UniProt:Q9XD84
dbId	9926981
disease	[Disease:3134792] bacterial infectious disease
displayName	Bam complex inserts Hbp into outer membrane
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
followingEvent	[Reaction:R-HSA-9926963] Hbp cis-autocleaves - Homo sapiens
input	[Complex:R-ECO-9961776] Hbp:Chaperones [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9927036] Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence [LiteratureReference:9926972] Roles of periplasmic chaperone proteins in the biogenesis of serine protease autotransporters of Enterobacteriaceae [LiteratureReference:9927024] Interaction of FkpA, a peptidyl-prolyl cis/trans isomerase with EspP autotransporter protein [LiteratureReference:9927031] Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane [LiteratureReference:9926990] Requirement for YaeT in the outer membrane assembly of autotransporter proteins [LiteratureReference:9926978] The essential ?-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis [LiteratureReference:9927042] ?-Barrel Assembly Machinery (BAM) Complex as Novel Antibacterial Drug Target [LiteratureReference:9927049] Reconstitution of outer membrane protein assembly from purified components [LiteratureReference:9927010] The reconstituted Escherichia coli Bam complex catalyzes multiple rounds of ?-barrel assembly [LiteratureReference:9926994] Lateral opening in the intact ?-barrel assembly machinery captured by cryo-EM [LiteratureReference:9933023] EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3/C3b and C5 [LiteratureReference:9933019] The Serine Protease Pic From Enteroaggregative Escherichia coli Mediates Immune Evasion by the Direct Cleavage of Complement Proteins [LiteratureReference:9933027] The TibA adhesin/invasin from enterotoxigenic Escherichia coli is self recognizing and induces bacterial aggregation and biofilm formation [LiteratureReference:9927019] Serine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream
maxDepth	1
modified	[InstanceEdit:9971731] Matthews, Lisa, 2025-11-10
name	Bam complex inserts Hbp into outer membrane
output	[EntityWithAccessionedSequence:R-ECO-9926950] Hbp [cell outer membrane] [DefinedSet:R-ECO-9926958] Periplasmic chaperones [periplasmic space]
previousReviewStatus	[ReviewStatus:9821380] one star
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9926981
summation	[Summation:9926969] The bacterial ?-Barrel Assembly Machinery (Bam) complex inse...
updateTrackers	[UpdateTracker:9964769] Update Tracker - [Reaction:9926981] Bam complex inserts Hbp into outer membrane - v94:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9964769] Update Tracker - [Reaction:9926981] Bam complex inserts Hbp into outer membrane - v94:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-9760173] Secretion of toxins
(precedingEvent)	[Reaction:R-HSA-9926963] Hbp cis-autocleaves

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