Reactome | Requirement by 'HSPA5 [endoplasmic reticulum lumen]'

Schema > Requirement > Entries

activity	[GO_MolecularFunction:9750509] ATP-dependent protein folding chaperone
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
dbId	9920072
displayName	Requirement by 'HSPA5 [endoplasmic reticulum lumen]'
modified	[InstanceEdit:9966304] Stephan, Ralf, 2025-09-15
regulatedEntity	[BlackBoxEvent:R-HSA-9919011] Pre-NS1 folds and is N-glycosylated - Homo sapiens [BlackBoxEvent:R-HSA-9918810] HyPro-polyprotein folds - Homo sapiens
regulator	[EntityWithAccessionedSequence:R-HSA-387190] HSPA5 [endoplasmic reticulum lumen]
schemaClass	Requirement

(regulatedBy)	[BlackBoxEvent:R-HSA-9919011] Pre-NS1 folds and is N-glycosylated [BlackBoxEvent:R-HSA-9918810] HyPro-polyprotein folds
(regulation)	[RegulationReference:9945585] Requirement by 'HSPA5 [endoplasmic reticulum lumen]' Dengue virus NS1 secretion is regulated via importin-subunit ?1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

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