Proline hydroxylases hydroxylate Polyprotein

Stable Identifier
R-HSA-9918779
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Proline hydroxylases hydroxylate Polyprotein
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Host collagen prolyl hydroxylases P4HA1 and P4HA2 cotranslationally catalyze the modification of several prolyl residues on DENV polyprotein to hydroxyproline. These modifications protect NS2B from aggregation and support proper polyprotein folding/stability. DENV additionally recruits the collagen-specific chaperone Hsp47/SERPINH1 and ER-resident prolyl isomerases FKBP10 and FKBP11 (Aviner et al., 2021).
Literature References
PubMed ID Title Journal Year
34408324 Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis

Aviner, R, Li, KH, Frydman, J, Andino, R

Nature 2021
Participants
Input
Output
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as an event of
Catalyst Activity

peptidyl-proline 4-dioxygenase activity of Prolyl 4-hydroxylases [endoplasmic reticulum lumen]

Physical Entity
Prolyl 4-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
Activity
peptidyl-proline 4-dioxygenase activity (GO:0031545)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
RHEA
Mondo
Authored
Stephan, R  (2024-08-18)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-18)
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