Reactome | Mitochondrial H2O2 decarboxylates PYR to acetate

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Mitochondrial H2O2 decarboxylates PYR to acetate Show undefined attributes

authored	[InstanceEdit:9861650] Stephan, Ralf, 2024-02-21
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9861650] Stephan, Ralf, 2024-02-21
dbId	9861745
displayName	Mitochondrial H2O2 decarboxylates PYR to acetate
edited	[InstanceEdit:9862190] Stephan, Ralf, 2024-02-23
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-1614617] H2O2 [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9861561] Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals
maxDepth	1
modified	[InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	Mitochondrial H2O2 decarboxylates PYR to acetate
output	[SimpleEntity:R-ALL-113539] CH3COO- [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-3299680] SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) - Homo sapiens [Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-9012016] FAHD1 dimer hydrolyses OA to PYR - Homo sapiens [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR - Homo sapiens [Reaction:R-HSA-9012349] ME3 tetramer decarboxylates MAL to PYR - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9861745
summation	[Summation:9861567] In the presence of hydrogen peroxide (H2O2), pyruvate (PYR) ...

Referrals

(hasEvent)

[Pathway:R-HSA-70268] Pyruvate metabolism

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