In the presence of hydrogen peroxide (H2O2), pyruvate (PYR) ...

created [InstanceEdit:9861650] Stephan, Ralf, 2024-02-21
dbId 9861567
displayName In the presence of hydrogen peroxide (H2O2), pyruvate (PYR) ...
schemaClass Summation
text In the presence of hydrogen peroxide (H2O2), pyruvate (PYR) is converted to acetate non-enzymatically. H2O2 is the end product of reactive oxygen species (ROS) degradation, usually from the reduction of superoxide (O2-). Under typical cell culture conditions, when there is active PDH and aKGDH, ROS contribute to around 5-15% of the acetate production. Thus, pyruvate may naturally function as a ROS scavenger (Liu et al., 2018).
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