Reactome | FAHD1 dimer hydrolyses OA to PYR

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FAHD1 dimer hydrolyses OA to PYR Show undefined attributes

authored	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
catalystActivity	[CatalystActivity:9012042] oxaloacetate decarboxylase activity of FAHD1:Mg2+ dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
crossReference	[DatabaseIdentifier:12667621] RHEA:15642 [DatabaseIdentifier:9861641] RHEA:15642
dbId	9012016
displayName	FAHD1 dimer hydrolyses OA to PYR
edited	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens [Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT - Homo sapiens [Reaction:R-HSA-9861745] Mitochondrial H2O2 decarboxylates PYR to acetate - Homo sapiens [Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Homo sapiens
input	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012047] X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880 [LiteratureReference:9012028] Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	FAHD1 dimer hydrolyses OA to PYR
orthologousEvent	[Reaction:R-SSC-9012016] FAHD1 dimer hydrolyses OA to PYR - Sus scrofa [Reaction:R-DRE-9012016] FAHD1 dimer hydrolyses OA to PYR - Danio rerio [Reaction:R-DDI-9012016] FAHD1 dimer hydrolyses OA to PYR - Dictyostelium discoideum [Reaction:R-GGA-9012016] FAHD1 dimer hydrolyses OA to PYR - Gallus gallus [Reaction:R-XTR-9012016] FAHD1 dimer hydrolyses OA to PYR - Xenopus tropicalis [Reaction:R-SCE-9012016] FAHD1 dimer hydrolyses OA to PYR - Saccharomyces cerevisiae [Reaction:R-SPO-9012016] FAHD1 dimer hydrolyses OA to PYR - Schizosaccharomyces pombe [Reaction:R-CEL-9012016] FAHD1 dimer hydrolyses OA to PYR - Caenorhabditis elegans [Reaction:R-DME-9012016] FAHD1 dimer hydrolyses OA to PYR - Drosophila melanogaster [Reaction:R-BTA-9012016] FAHD1 dimer hydrolyses OA to PYR - Bos taurus [Reaction:R-CFA-9012016] FAHD1 dimer hydrolyses OA to PYR - Canis familiaris [Reaction:R-RNO-9012016] FAHD1 dimer hydrolyses OA to PYR - Rattus norvegicus [Reaction:R-MMU-9012016] FAHD1 dimer hydrolyses OA to PYR - Mus musculus
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens [Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9034691] Jansen-Duerr, Pidder, Weiss, Alexander, 2018-01-10 [InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9012016
summation	[Summation:9012059] Fumarylacetoacetate hydrolase domain containing protein 1 (F...
updateTrackers	[UpdateTracker:9864198] Update Tracker - [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR - v88:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9864198] Update Tracker - [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR - v88:[addInput]
(hasEvent)	[Pathway:R-HSA-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-HSA-9861745] Mitochondrial H2O2 decarboxylates PYR to acetate [Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT [Reaction:R-HSA-70501] PC carboxylates PYR to OA [Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT

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